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Year 2024, Volume: 8 Issue: 1, 10 - 39, 15.01.2024

Emmanuel Edache Adamu Uzairu Paul Andrew Mamza Gideon Adamu Shallangwa

https://doi.org/10.33435/tcandtc.1196019

Abstract

References

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Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein

Year 2024, Volume: 8 Issue: 1, 10 - 39, 15.01.2024

Emmanuel Edache Adamu Uzairu Paul Andrew Mamza Gideon Adamu Shallangwa

https://doi.org/10.33435/tcandtc.1196019

Abstract

The propagation of emerging diseases and the expensive cost and time lost by using the classic methods, especially in the current scenario with the world being plagued by SARS-CoV-2 and Chlamydia trachomatis diseases, make finding another way to invent new medication very important. That's why we used computational approaches to predict protein-ligand interactions of thiazolino 2-pyridone amide derivatives. The high-throughput virtual screening requires extensive combing through existing datasets in the hope of finding possible matches to screen for new molecules able to inhibit SARS-CoV-2 and Chlamydia trachomatis diseases. In this study, 46 thiazolino-2-pyridone amide derivatives were chosen for planning the powerful inhibitors by utilizing various strategies: QSAR analysis, phylogenetic analysis, homology modeling, docking simulation, molecular dynamics (MD) simulation, as well as ADMET Screening. The 2D QSAR investigation uncovers that these compounds show a satisfactory connection with bioactivity. From that point onward, phylogenetic analysis and homology modeling were used to model the selected receptors, which were then evaluated using both the SAVES and PROSA servers, indicating the best correctness of the modeled protein with the experimental results. Additionally, a docking simulation investigation was carried out to comprehend the 46 thiazolino-2-pyridone amide derivatives' interactions with homologous proteins. Additionally, MD simulations coupled with MM/GBSA verified the chosen complex systems' stability over 1000 ps. Two compounds were chosen as possible inhibitors based on these findings. The expected thiazolino-2-pyridone amide's oral bioavailability and toxicity have been discovered under the ADMET. Thus, these discoveries can be leveraged to develop novel molecules with the necessary action.

Keywords

SARS-CoV-2 Chlamydia trachomatis Thiazolino 2-pyridone amide Docking MD simulations ADMET and MM/GBSA calculation

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There are 87 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Article
Authors

Emmanuel Edache 0000-0002-5485-0583

Adamu Uzairu This is me 0000-0002-6973-6361

Paul Andrew Mamza This is me

Gideon Adamu Shallangwa 0000-0002-0700-9898

Early Pub Date May 26, 2023
Publication Date January 15, 2024
Submission Date October 28, 2022
Published in Issue Year 2024 Volume: 8 Issue: 1

Cite

APA Edache, E., Uzairu, A., Mamza, P. A., Shallangwa, G. A. (2024). Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein. Turkish Computational and Theoretical Chemistry, 8(1), 10-39. https://doi.org/10.33435/tcandtc.1196019
AMA Edache E, Uzairu A, Mamza PA, Shallangwa GA. Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein. Turkish Comp Theo Chem (TC&TC). January 2024;8(1):10-39. doi:10.33435/tcandtc.1196019
Chicago Edache, Emmanuel, Adamu Uzairu, Paul Andrew Mamza, and Gideon Adamu Shallangwa. “Molecular Phylogeny, Sequence-Based Drug Design, Docking Built Virtual Screening, Dynamics Simulations, and ADMET Properties of Thiazolino 2-Pyridone Amide Derivatives As an Inhibitor of Chlamydia Trachomatis and SARS-CoV-2 Protein”. Turkish Computational and Theoretical Chemistry 8, no. 1 (January 2024): 10-39. https://doi.org/10.33435/tcandtc.1196019.
EndNote Edache E, Uzairu A, Mamza PA, Shallangwa GA (January 1, 2024) Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein. Turkish Computational and Theoretical Chemistry 8 1 10–39.
IEEE E. Edache, A. Uzairu, P. A. Mamza, and G. A. Shallangwa, “Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein”, Turkish Comp Theo Chem (TC&TC), vol. 8, no. 1, pp. 10–39, 2024, doi: 10.33435/tcandtc.1196019.
ISNAD Edache, Emmanuel et al. “Molecular Phylogeny, Sequence-Based Drug Design, Docking Built Virtual Screening, Dynamics Simulations, and ADMET Properties of Thiazolino 2-Pyridone Amide Derivatives As an Inhibitor of Chlamydia Trachomatis and SARS-CoV-2 Protein”. Turkish Computational and Theoretical Chemistry 8/1 (January 2024), 10-39. https://doi.org/10.33435/tcandtc.1196019.
JAMA Edache E, Uzairu A, Mamza PA, Shallangwa GA. Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein. Turkish Comp Theo Chem (TC&TC). 2024;8:10–39.
MLA Edache, Emmanuel et al. “Molecular Phylogeny, Sequence-Based Drug Design, Docking Built Virtual Screening, Dynamics Simulations, and ADMET Properties of Thiazolino 2-Pyridone Amide Derivatives As an Inhibitor of Chlamydia Trachomatis and SARS-CoV-2 Protein”. Turkish Computational and Theoretical Chemistry, vol. 8, no. 1, 2024, pp. 10-39, doi:10.33435/tcandtc.1196019.
Vancouver Edache E, Uzairu A, Mamza PA, Shallangwa GA. Molecular phylogeny, Sequence-based drug design, Docking built virtual screening, dynamics simulations, and ADMET properties of thiazolino 2-pyridone amide derivatives as an inhibitor of Chlamydia trachomatis and SARS-CoV-2 protein. Turkish Comp Theo Chem (TC&TC). 2024;8(1):10-39.

Journal Full Title: Turkish Computational and Theoretical Chemistry


Journal Abbreviated Title: Turkish Comp Theo Chem (TC&TC)