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Ameliorative Effect of a Vanadium-thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats

Year 2024, Volume: 28 Issue: 1, 133 - 144, 29.02.2024
https://doi.org/10.16984/saufenbilder.1289079

Abstract

Recently, we have shown that oral administrations of an oxidovanadium (IV) complex, VOL, with tetradentate thiosemicarbazone ligand normalizes hyperglycemia of streptozotocin-induced diabetic rats (STZ-rats). For the development of vanadium compounds that exhibit insulin-like behavior, it is essential to know some of the pharmacokinetic properties of these complexes. The goal of the current research is to examine the healing effect of new sythesed VOL complex on the oxidative stress parameters of diabetic stomac tissue. Rats used in the experiments were divided as control, VOL+control, diabetic and diabetic+VOL. The rats were sacrificed after 12 days of the experimental period. The levels of glutathione, lipid peroxidation, non-enzymatic glycosylation, advanced oxidized protein products levels and the activities of some enzymes were measured in stomach tissue of all the experimental animals. Although VOL treatment to diabetic rats increased the stomach glutathione levels; lipid peroxidation, non-enzymatic glycosylation and advanced oxidized protein products levels were decreased. Also, the activities of catalase, superoxide dismutase, glutathione-S-transferase, glutathione peroxidase, glutathione reductase and carbonic anhydrase were increased in VOL treated diabetic group. Whereas, lactate dehydrogenase and xanthine oxidase activities were decreased. According to the obtained outcomes, it can be said that VOL treatment has a healing effect on the stomach tissue of diabetic rats. This effect provided by VOL is most likely due to the insulin-like and antioxidant activity of the complex. In conclusion, we can say that VOL may be a suitable candidate for diabetes treatment.

Project Number

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References

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Year 2024, Volume: 28 Issue: 1, 133 - 144, 29.02.2024
https://doi.org/10.16984/saufenbilder.1289079

Abstract

Supporting Institution

yok

Project Number

yok

Thanks

yok

References

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  • [24] B. Atasever, B. Ülküseven, T. Bal-Demirci, S. Erdem-Kuruca, Z. Solakoğlu, “Cytotoxic activities of new iron (III) and nickel (II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells,” Investigational New Drugs, vol. 28, no. 4, pp. 421-432, 2010.
  • [25] T. Demirci, Y. Köseoğlu, S. Güner, B. Ülküseven, “Oxovanadium (IV) complexes of bromo-and methoxy substituted N1, N4-diarylidene-S-methylthiosemicarbazones,” Open Chemistry, vol. 4, no. 1, pp. 149-159, 2006.
  • [26] M. Melchior, S. J. Rettig, B. D. Liboiron, K. H. Thompson, V. G. Yuen, J. H. McNeill, C. Orvig, “Insulin-enhancing vanadium (III) complexes,” Inorganic Chemistry, vol. 40, no. 18, pp. 4686–4690, 2001.
  • [27] A. Junod, A. E. Lambert, W. Stauffacher, A. E. Renold, “Diabetogenic action of streptozotocin: relationship of dose to metabolic response,” The Journal of Clinical Investigation, vol. 48, no. 11, pp. 2129–2139, 1969.
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There are 59 citations in total.

Details

Primary Language English
Subjects Chemical Engineering
Journal Section Research Articles
Authors

Fatma Gülnaz Karakuş 0000-0003-2086-2444

Sevim Tunalı 0000-0003-3363-1290

Tülay Bal-demirci 0000-0003-4663-2209

Bahri Ülküseven 0000-0001-6342-1505

Refiye Yanardağ 0000-0003-4185-4363

Project Number yok
Early Pub Date February 27, 2024
Publication Date February 29, 2024
Submission Date April 28, 2023
Acceptance Date October 21, 2023
Published in Issue Year 2024 Volume: 28 Issue: 1

Cite

APA Karakuş, F. G., Tunalı, S., Bal-demirci, T., Ülküseven, B., et al. (2024). Ameliorative Effect of a Vanadium-thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats. Sakarya University Journal of Science, 28(1), 133-144. https://doi.org/10.16984/saufenbilder.1289079
AMA Karakuş FG, Tunalı S, Bal-demirci T, Ülküseven B, Yanardağ R. Ameliorative Effect of a Vanadium-thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats. SAUJS. February 2024;28(1):133-144. doi:10.16984/saufenbilder.1289079
Chicago Karakuş, Fatma Gülnaz, Sevim Tunalı, Tülay Bal-demirci, Bahri Ülküseven, and Refiye Yanardağ. “Ameliorative Effect of a Vanadium-Thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats”. Sakarya University Journal of Science 28, no. 1 (February 2024): 133-44. https://doi.org/10.16984/saufenbilder.1289079.
EndNote Karakuş FG, Tunalı S, Bal-demirci T, Ülküseven B, Yanardağ R (February 1, 2024) Ameliorative Effect of a Vanadium-thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats. Sakarya University Journal of Science 28 1 133–144.
IEEE F. G. Karakuş, S. Tunalı, T. Bal-demirci, B. Ülküseven, and R. Yanardağ, “Ameliorative Effect of a Vanadium-thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats”, SAUJS, vol. 28, no. 1, pp. 133–144, 2024, doi: 10.16984/saufenbilder.1289079.
ISNAD Karakuş, Fatma Gülnaz et al. “Ameliorative Effect of a Vanadium-Thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats”. Sakarya University Journal of Science 28/1 (February 2024), 133-144. https://doi.org/10.16984/saufenbilder.1289079.
JAMA Karakuş FG, Tunalı S, Bal-demirci T, Ülküseven B, Yanardağ R. Ameliorative Effect of a Vanadium-thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats. SAUJS. 2024;28:133–144.
MLA Karakuş, Fatma Gülnaz et al. “Ameliorative Effect of a Vanadium-Thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats”. Sakarya University Journal of Science, vol. 28, no. 1, 2024, pp. 133-44, doi:10.16984/saufenbilder.1289079.
Vancouver Karakuş FG, Tunalı S, Bal-demirci T, Ülküseven B, Yanardağ R. Ameliorative Effect of a Vanadium-thiosemicarbazone Complex on Oxidative Stress in Stomach Tissue of Experimental Diabetic Rats. SAUJS. 2024;28(1):133-44.