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Year 2021, Volume: 1 Issue: 1, 27 - 32, 17.01.2023

Nurcan Kılıç Baygutalp

Abstract

References

  • 1. Boström PJ, Wu MP, Jedrychowski A, Korde L, Ye JC, Lo, et al. A PGC1-αdependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481(7382):463-8.
  • 2. Lehnig AC, Stanford KI. Exercise-induced adaptations to white and brown adipose tissue. J Exp Biol 2018;221(Pt Suppl 1).
  • 3. DiSpirito JR, Mathis D. Immunological contributions to adipose tissue homeostasis. Semin Immunol 2015;27(5):315-21.
  • 4. Luo L, Liu M. Adipose tissue in control of metabolism. J Endocrinol 2016;231(3):R77-r99.
  • 5. Yamauchi TJ, Kamon H, Waki Y, Terauchi N, Kubota K, Hara, et al. The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7(8):941-6.
  • 6. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7(8):947-53.
  • 7. Combs, TP, UB, Pajvani AH, Berg Y, Lin LA, Jelicks M, Laplante, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004;145(1):367-83.
  • 8. Higashiura KN, Ura J, Ohata N, Togashi S, Takagi S, Saitoh, et al. Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations. Clin Endocrinol (Oxf) 2004;61(6):753-9.
  • 9. Spranger JA, Kroke M, Möhlig MM, Bergmann M, Ristow H, Boeing, et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003;361(9353):226-8.
  • 10. Guerre-Millo M. Adipose tissue and adipokines: for better or worse. Diabetes Metab 2004;30(1):13-9.
  • 11. Wang ZV, Scherer PE. Adiponectin, the past two decades. J Mol Cell Biol 2016;8(2):93-100.
  • 12. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17(1):4-12.
  • 13. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000;96(5):1723-32.
  • 14. Uygungelen B, İçağasıoğlu S, Acıbucu F, Kılıçlı F, Uslu A, Gül İ. Serum adiponectin level in hypertensive patients and its association with atherosclerotic risk factors. Cumhuriyet Medical Journal 2013;35(2):206-14.
  • 15. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, et al. Association of hypoadiponectinemia with coronary artery disease in men. Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):85-9.
  • 16. Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, et al. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002;51(7):2325-8.
  • 17. Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, et al. Genomic structure and mutations in adipose-specific gene, adiponectin. International journal of obesity 2000;24(7):861-8.
  • 18. Panati K, Suneetha Y, Narala VR. Irisin/FNDC5--An updated review. Eur Rev Med Pharmacol Sci 2016;20(4):689-97.
  • 19. El-Lebedy DH, Ibrahim AA, Ashmawy IO. Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus. Diabetes Metab Syndr 2018;12(5):643-8.
  • 20. Faienza MF, Brunetti G, Sanesi L, Colaianni G, Celi M, Piacente L, et al. High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes. Diabetes Res Clin Pract 2018;141:10-7.
  • 21. Abdu Allah AM, Hammoudah SA, Abd El Gayed EM, El-Attar LM, ShehabEldin WA. Obesity and its Association with Irisin Level Among Individuals with FNDC5/Irisin Gene Variants RS16835198 and RS726344. Protein Pept Lett 2018;25(6):560-9.
  • 22. Salem H, Yatchenko Y, Anosov M, Rosenfeld T, Altarescu T, GrisaruGranovsky S, et al. Maternal and neonatal irisin precursor gene FNDC5 polymorphism is associated with preterm birth. Gene 2018;649:58-62.
  • 23. Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 2013;98(4):E769-78.
  • 24. Crujeiras AB, Pardo M, Casanueva FF. Irisin: 'fat' or artefact. Clin Endocrinol (Oxf) 2015;82(4):467-74.
  • 25. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012;61(12):1725-38.

Adipose Tissue As an Endocrine Organ: A Perspective From Adiponectine and Irisin

Year 2021, Volume: 1 Issue: 1, 27 - 32, 17.01.2023

Nurcan Kılıç Baygutalp

Abstract

In recent years, adipose tissue has been defined as a new endocrine organ via its paracrine, autocrine and endocrine effects. With the secreted hormones and cytokines it plays a major role in the regulation and integration of metabolism. The metabolic pathways involvin these hormones and cytokines including insulin sensitivity show a connection with the pathogenesis of obesity, type II diabetes mellitus, metabolic syndrome, inflammatory diseases, many chronic diseases and even cancer. Adipokines or adipocytokines are cytokines secreted by adipose tissue. In this mini-review, information about two of the most important adipokines, adiponectin and irisin, is given and their important effects are presented to the attention of the reader.

Keywords

Adiponectin adipose tissue endocrine irisin

References

  • 1. Boström PJ, Wu MP, Jedrychowski A, Korde L, Ye JC, Lo, et al. A PGC1-αdependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 2012;481(7382):463-8.
  • 2. Lehnig AC, Stanford KI. Exercise-induced adaptations to white and brown adipose tissue. J Exp Biol 2018;221(Pt Suppl 1).
  • 3. DiSpirito JR, Mathis D. Immunological contributions to adipose tissue homeostasis. Semin Immunol 2015;27(5):315-21.
  • 4. Luo L, Liu M. Adipose tissue in control of metabolism. J Endocrinol 2016;231(3):R77-r99.
  • 5. Yamauchi TJ, Kamon H, Waki Y, Terauchi N, Kubota K, Hara, et al. The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7(8):941-6.
  • 6. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med 2001;7(8):947-53.
  • 7. Combs, TP, UB, Pajvani AH, Berg Y, Lin LA, Jelicks M, Laplante, et al. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology 2004;145(1):367-83.
  • 8. Higashiura KN, Ura J, Ohata N, Togashi S, Takagi S, Saitoh, et al. Correlations of adiponectin level with insulin resistance and atherosclerosis in Japanese male populations. Clin Endocrinol (Oxf) 2004;61(6):753-9.
  • 9. Spranger JA, Kroke M, Möhlig MM, Bergmann M, Ristow H, Boeing, et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet 2003;361(9353):226-8.
  • 10. Guerre-Millo M. Adipose tissue and adipokines: for better or worse. Diabetes Metab 2004;30(1):13-9.
  • 11. Wang ZV, Scherer PE. Adiponectin, the past two decades. J Mol Cell Biol 2016;8(2):93-100.
  • 12. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006;17(1):4-12.
  • 13. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 2000;96(5):1723-32.
  • 14. Uygungelen B, İçağasıoğlu S, Acıbucu F, Kılıçlı F, Uslu A, Gül İ. Serum adiponectin level in hypertensive patients and its association with atherosclerotic risk factors. Cumhuriyet Medical Journal 2013;35(2):206-14.
  • 15. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, et al. Association of hypoadiponectinemia with coronary artery disease in men. Arteriosclerosis, thrombosis, and vascular biology 2003;23(1):85-9.
  • 16. Kondo H, Shimomura I, Matsukawa Y, Kumada M, Takahashi M, Matsuda M, et al. Association of adiponectin mutation with type 2 diabetes: a candidate gene for the insulin resistance syndrome. Diabetes 2002;51(7):2325-8.
  • 17. Takahashi M, Arita Y, Yamagata K, Matsukawa Y, Okutomi K, Horie M, et al. Genomic structure and mutations in adipose-specific gene, adiponectin. International journal of obesity 2000;24(7):861-8.
  • 18. Panati K, Suneetha Y, Narala VR. Irisin/FNDC5--An updated review. Eur Rev Med Pharmacol Sci 2016;20(4):689-97.
  • 19. El-Lebedy DH, Ibrahim AA, Ashmawy IO. Novel adipokines vaspin and irisin as risk biomarkers for cardiovascular diseases in type 2 diabetes mellitus. Diabetes Metab Syndr 2018;12(5):643-8.
  • 20. Faienza MF, Brunetti G, Sanesi L, Colaianni G, Celi M, Piacente L, et al. High irisin levels are associated with better glycemic control and bone health in children with Type 1 diabetes. Diabetes Res Clin Pract 2018;141:10-7.
  • 21. Abdu Allah AM, Hammoudah SA, Abd El Gayed EM, El-Attar LM, ShehabEldin WA. Obesity and its Association with Irisin Level Among Individuals with FNDC5/Irisin Gene Variants RS16835198 and RS726344. Protein Pept Lett 2018;25(6):560-9.
  • 22. Salem H, Yatchenko Y, Anosov M, Rosenfeld T, Altarescu T, GrisaruGranovsky S, et al. Maternal and neonatal irisin precursor gene FNDC5 polymorphism is associated with preterm birth. Gene 2018;649:58-62.
  • 23. Moreno-Navarrete JM, Ortega F, Serrano M, Guerra E, Pardo G, Tinahones F, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. J Clin Endocrinol Metab 2013;98(4):E769-78.
  • 24. Crujeiras AB, Pardo M, Casanueva FF. Irisin: 'fat' or artefact. Clin Endocrinol (Oxf) 2015;82(4):467-74.
  • 25. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider BE, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism 2012;61(12):1725-38.
There are 25 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences
Journal Section Reviews
Authors

Nurcan Kılıç Baygutalp 0000-0002-3584-5252

Publication Date January 17, 2023
Published in Issue Year 2021 Volume: 1 Issue: 1

Cite

EndNote Kılıç Baygutalp N (January 1, 2023) Adipose Tissue As an Endocrine Organ: A Perspective From Adiponectine and Irisin. International Journal of PharmATA 1 1 27–32.
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