Artemisia annua L. known as sweet wormwood in ancient literature is an essential oil bearing and medicinal aromatic plant and belongs to Asteraceae family. It has been used for many years in traditional eastern medicine especially in the treatment of malaria and some parasitic diseases, and it gives successful results. Recently, it has been addressed with its potential effect against coronavirus. In this study, naturally growing Artemisia annua L. sample in Uludag, in Bursa province of Turkey, was used as raw drug. The aim of this study is to determine the yields of artemisinin in three different solvent phase extracts using High Performance Liquid Chromatography (HPLC) and examine cytotoxic/genotoxic effect of total ethanol extract on epithelial cells isolated from human bronchial epithelium. The highest amount of artemisinin was found as 0.19 mg/g in ethanol extract. As a result of cell toxicity assay, no cytotoxicity or genotoxicity effect was observed at doses less than 500 µg/mL.
medicinal aromatic plants Artemisia annua L. chromatography phytotherapy cell toxicity covid19
The Scientific Research Project Council of Bursa Technical University
200COVID02
This study was financially supported by the Scientific Research Project Council of Bursa Technical University (Turkey, Project number: 200COVID02), for which we are thankful. The authors are also grateful to Yasam Pharma Co., for plant sample supply and thankful to Bursa Technical University Central Research Laboratory and Uludag University Genetics and Toxicology Laboratory for their support.
200COVID02
Primary Language | English |
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Subjects | Engineering |
Journal Section | Research Articles |
Authors | |
Project Number | 200COVID02 |
Early Pub Date | February 22, 2022 |
Publication Date | June 8, 2022 |
Published in Issue | Year 2022Volume: 6 Issue: 1 |
The works published in Journal of Innovative Science and Engineering (JISE) are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.