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The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice

Year 2023, Volume: 53 Issue: 2, 199 - 210, 30.08.2023
https://doi.org/10.26650/IstanbulJPharm.2023.1005935

Abstract

Background and Aims: The aim of this study was to investigate the histological and biochemical effects of the antioxidant combination on liver tissue of streptozotocin (STZ)-induced diabetic mice.
Methods: Five groups of mice were given a citrate buffer (CB), the antioxidant solvents (AS), the antioxidant combination (A) (α-lipoic acid, selenium, and vitamin E), STZ (D), the antioxidant combination and STZ (A+D). The mice were sacrificed, and their liver tissues were taken out. The liver tissues were examined histologically and immune+ cell numbers of cannabinoid receptors (CB1R and CB2R) were detected. Xanthine oxidase (XO) activity, glutathione (GSH) and lipid peroxidation (LPO) levels, superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), γ-glutamyl transferase (GGT), paraoxonase (PON), glucose-6-phosphate dehydrogenase (G6PD) activities, protein carbonyl content (PCC) and advanced oxidation protein product (AOPP), sialic acid, fucose, hexose and hydroxyproline (OH-proline) levels were biochemically determined.
Results: Certain degenerative changes were reduced in the A+D group compared histologically to the D group. There were no significant changes in the number of CB1R immune+ cells. The number of CB2R immune+ cells was significantly reduced in the D group compared to the CB group. The GSH level, CAT, SOD, GR, GPx, GST, PON, and G6PD activities were increased while XO and GGT activity, LPO, PCC, AOPP, hexose, fucose, sialic acid, and OH-proline level were biochemically decreased in the A+D group compared to the D group.
Conclusion: The use of the antioxidant combination had a positive effect on the livers of diabetic mice with histochemical and biochemical changes, while there was no effect on the regulation of cannabinoid receptors expressions.

Supporting Institution

İstanbul Üniversitesi Bilimsel Araştırma Projeleri Birimi

Project Number

T-891 ve BEK-2017-24663.

Thanks

This study was supported by the Research Fund of Istanbul University. Project Numbers T-891 and BEK-2017-24663.

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Year 2023, Volume: 53 Issue: 2, 199 - 210, 30.08.2023
https://doi.org/10.26650/IstanbulJPharm.2023.1005935

Abstract

Project Number

T-891 ve BEK-2017-24663.

References

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There are 91 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Original Article
Authors

Ayşe Karatuğ Kaçar 0000-0001-6032-470X

Onur Ertik 0000-0002-9686-8634

Zeynep Mine Coşkun 0000-0003-4791-6537

Sema Bolkent 0000-0001-8463-5561

Refiye Yanardağ 0000-0003-4185-4363

Şehnaz Bolkent 0000-0002-1112-5162

Project Number T-891 ve BEK-2017-24663.
Publication Date August 30, 2023
Submission Date October 7, 2021
Published in Issue Year 2023 Volume: 53 Issue: 2

Cite

APA Karatuğ Kaçar, A., Ertik, O., Coşkun, Z. M., Bolkent, S., et al. (2023). The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. İstanbul Journal of Pharmacy, 53(2), 199-210. https://doi.org/10.26650/IstanbulJPharm.2023.1005935
AMA Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş. The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. iujp. August 2023;53(2):199-210. doi:10.26650/IstanbulJPharm.2023.1005935
Chicago Karatuğ Kaçar, Ayşe, Onur Ertik, Zeynep Mine Coşkun, Sema Bolkent, Refiye Yanardağ, and Şehnaz Bolkent. “The Combined Ameliorative Effects of α-Lipoic Acid, Selenium, and Vitamin E on the Livers of STZ-Diabetic Mice”. İstanbul Journal of Pharmacy 53, no. 2 (August 2023): 199-210. https://doi.org/10.26650/IstanbulJPharm.2023.1005935.
EndNote Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş (August 1, 2023) The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. İstanbul Journal of Pharmacy 53 2 199–210.
IEEE A. Karatuğ Kaçar, O. Ertik, Z. M. Coşkun, S. Bolkent, R. Yanardağ, and Ş. Bolkent, “The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice”, iujp, vol. 53, no. 2, pp. 199–210, 2023, doi: 10.26650/IstanbulJPharm.2023.1005935.
ISNAD Karatuğ Kaçar, Ayşe et al. “The Combined Ameliorative Effects of α-Lipoic Acid, Selenium, and Vitamin E on the Livers of STZ-Diabetic Mice”. İstanbul Journal of Pharmacy 53/2 (August 2023), 199-210. https://doi.org/10.26650/IstanbulJPharm.2023.1005935.
JAMA Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş. The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. iujp. 2023;53:199–210.
MLA Karatuğ Kaçar, Ayşe et al. “The Combined Ameliorative Effects of α-Lipoic Acid, Selenium, and Vitamin E on the Livers of STZ-Diabetic Mice”. İstanbul Journal of Pharmacy, vol. 53, no. 2, 2023, pp. 199-10, doi:10.26650/IstanbulJPharm.2023.1005935.
Vancouver Karatuğ Kaçar A, Ertik O, Coşkun ZM, Bolkent S, Yanardağ R, Bolkent Ş. The combined ameliorative effects of α-lipoic acid, selenium, and vitamin E on the livers of STZ-diabetic mice. iujp. 2023;53(2):199-210.