Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey

Belkıs Yaşa; Naile Angın; Murat Ertaş; Sibel Tuna; Aycan Çınar

doi:10.38088/jise.1033063

EN

Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey

Abstract

Artemisia annua L. known as sweet wormwood in ancient literature is an essential oil bearing and medicinal aromatic plant and belongs to Asteraceae family. It has been used for many years in traditional eastern medicine especially in the treatment of malaria and some parasitic diseases, and it gives successful results. Recently, it has been addressed with its potential effect against coronavirus. In this study, naturally growing Artemisia annua L. sample in Uludag, in Bursa province of Turkey, was used as raw drug. The aim of this study is to determine the yields of artemisinin in three different solvent phase extracts using High Performance Liquid Chromatography (HPLC) and examine cytotoxic/genotoxic effect of total ethanol extract on epithelial cells isolated from human bronchial epithelium. The highest amount of artemisinin was found as 0.19 mg/g in ethanol extract. As a result of cell toxicity assay, no cytotoxicity or genotoxicity effect was observed at doses less than 500 µg/mL.

Keywords

Supporting Institution

The Scientific Research Project Council of Bursa Technical University

Project Number

200COVID02

Thanks

This study was financially supported by the Scientific Research Project Council of Bursa Technical University (Turkey, Project number: 200COVID02), for which we are thankful. The authors are also grateful to Yasam Pharma Co., for plant sample supply and thankful to Bursa Technical University Central Research Laboratory and Uludag University Genetics and Toxicology Laboratory for their support.

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Details

Primary Language

English

Subjects

Engineering

Journal Section

Research Article

Authors

Belkıs Yaşa
0000-0001-8141-4579
Türkiye

Naile Angın
0000-0001-9874-9236
Türkiye

Murat Ertaş ^*
0000-0001-9218-5513
Türkiye

Sibel Tuna
0000-0002-4406-9048
Türkiye

Aycan Çınar
0000-0003-2038-725X
Türkiye

Publication Date

June 8, 2022

Submission Date

December 6, 2021

Acceptance Date

December 12, 2021

Published in Issue

Year 1970 Volume: 6 Number: 1

DOI

https://doi.org/10.38088/jise.1033063

IZ

https://izlik.org/JA76LN76MG

Cite

RIS / Bibtex

APA

Yaşa, B., Angın, N., Ertaş, M., Tuna, S., & Çınar, A. (2022). Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey. Journal of Innovative Science and Engineering, 6(1), 108-121. https://doi.org/10.38088/jise.1033063

AMA

1.Yaşa B, Angın N, Ertaş M, Tuna S, Çınar A. Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey. JISE. 2022;6(1):108-121. doi:10.38088/jise.1033063

Chicago

Yaşa, Belkıs, Naile Angın, Murat Ertaş, Sibel Tuna, and Aycan Çınar. 2022. “Artemisinin Yield and Cyto Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey”. Journal of Innovative Science and Engineering 6 (1): 108-21. https://doi.org/10.38088/jise.1033063.

EndNote

Yaşa B, Angın N, Ertaş M, Tuna S, Çınar A (June 1, 2022) Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey. Journal of Innovative Science and Engineering 6 1 108–121.

IEEE

[1]B. Yaşa, N. Angın, M. Ertaş, S. Tuna, and A. Çınar, “Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey”, JISE, vol. 6, no. 1, pp. 108–121, June 2022, doi: 10.38088/jise.1033063.

ISNAD

Yaşa, Belkıs - Angın, Naile - Ertaş, Murat - Tuna, Sibel - Çınar, Aycan. “Artemisinin Yield and Cyto Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey”. Journal of Innovative Science and Engineering 6/1 (June 1, 2022): 108-121. https://doi.org/10.38088/jise.1033063.

JAMA

1.Yaşa B, Angın N, Ertaş M, Tuna S, Çınar A. Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey. JISE. 2022;6:108–121.

MLA

Yaşa, Belkıs, et al. “Artemisinin Yield and Cyto Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey”. Journal of Innovative Science and Engineering, vol. 6, no. 1, June 2022, pp. 108-21, doi:10.38088/jise.1033063.

Vancouver

1.Belkıs Yaşa, Naile Angın, Murat Ertaş, Sibel Tuna, Aycan Çınar. Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey. JISE. 2022 Jun. 1;6(1):108-21. doi:10.38088/jise.1033063

Öz

Artemisinin Yield and Cyto/Genotoxic Properties of Naturally Grown Artemisia Annua L. In Uludag, Turkey

Abstract

Keywords

Supporting Institution

Project Number

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite