Natural products derived from plants play a significant role in drug discovery due to the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of the plant were boiled in water for 2 h then extracted with ethyl acetate. After evaporation of the solvent by rotary evaporator, the extract was subjected to column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative activity of isolated compound was tested against HeLa (human cervix carcinoma) cell lines by xCELLigence assay, and found out that the compound exhibited excellent activity.
Natural
products derived from plants play a significant role in drug discovery due to
the revealing a large variety of pharmaceutical effects. Kickxia spuriawas collected from Bingol, Turkey. Aerial parts of
the plant were boiled in water for 2 h then extracted with ethyl acetate. After
evaporation of the solvent by rotary evaporator, the extract was subjected to
column chromatography to yield the compound identified as 6,7-dimethoxy-5-hydroxyflavone by
spectroscopic method including 1D-, 2D-NMR, LC-TOF/MS. Antiproliferative
activity of isolated compound was tested against HeLa (human cervix carcinoma)
cell lines by xCELLigence assay, and found out that the compound exhibited
excellent activity.
Primary Language | English |
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Subjects | Structural Biology |
Journal Section | Articles |
Authors | |
Publication Date | December 20, 2017 |
Submission Date | May 4, 2017 |
Published in Issue | Year 2017 Volume: 4 Issue: 3, Special Issue 2 |