Abstract
References
- AEBI, H. 1984. [13] Catalase in vitro. In Methods in enzymology, 105:121-126.
- ANDERSON, D., YU, T.W., PHILLIPS, B., SCHMEZER, P. (1994). The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 307:261-271.
Abstract
It has been reported that baicalin (7-glucuronic acid,5,6-dihydroxyflavone; molecular weight= 446.36) has antioxidant, antitoxin and anti-inflammatory properties, antitumor, antiviral, hepatoprotective, antibacterial, anti-inflammatory and antidiarrheal effects. The purpose of the present study is determined the anti-genotoxic and antioxidative effects of baicalin against carbon tetrachloride in the human lymphocytes cell. For the study, the anti-genotoxic potential of baicalin was investigated by comet assay. In addition, biochemical analysis including superoxide dismutase, catalase activities and malondialdehyde level, were performed. According to the obtained results; when the concentrations were evaluated in terms of reducing the level of DNA damage, it was observed that baicalin gave the best results in the applications of 100 μM concentration. In conclusion, baicalin was determined to exhibit anti-genotoxic activity by virtue of its antioxidant potential, which is the genotoxic effect caused by carbon tetrachloride. Baicalin, an important compound for clinical applications and known to have a short half-life; more successful results can be obtained in treatment with high concentrations and repeated applications.
References
- AEBI, H. 1984. [13] Catalase in vitro. In Methods in enzymology, 105:121-126.
- ANDERSON, D., YU, T.W., PHILLIPS, B., SCHMEZER, P. (1994). The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the COMET assay, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 307:261-271.
Details
| Primary Language | English |
|---|---|
| Journal Section | makaleler |
| Authors | |
| Publication Date | May 30, 2021 |
| Published in Issue | Year 2021 Volume: 7 Issue: 1 |