Research Article
BibTex RIS Cite

Daidzeinin ovaryum iskemi reperfüzyonu hasarındaki koruyucu etkisi

Year 2022, Volume: 47 Issue: 1, 102 - 110, 31.03.2022
https://doi.org/10.17826/cumj.993250

Abstract

Amaç: Bu çalışmada, güçlü antioksidan daidzeinin (DZ) over iskemi ve reperfüzyon hasarı üzerindeki potansiyel etkisini araştırdık.
Gereç ve Yöntem: Toplam 42 adet dişi Sprague-Dawley sıçan rastgele yedi gruba ayrıldı. Deney modeli için, 3saatlik iskeminin ardından klempler çıkarıldı ve tekrar kan akışı sağlandı. Reperfüzyon 3 saatin sonunda sonlandırıldı. Daidzein, iskemi (I) ve iskemi ve reperfüzyon (I/R) işlemlerinden 30 dakika önce hayvanlara ağızdan 35 ve 70 mg/kg dozlarında uygulandı.
Bulgular: I ve I/R gruplarında IL-1β, IL 6 ve Caspase 3'ün şiddetli immünoreaktivite görüldü. I+DZ35 ve I/R+DZ35 gruplarında IL-1β, IL 6 ve Kaspaz 3'ün immünreaktivitesi orta düzeyde iken, I+DZ70 ve I/R+DZ70 gruplarında hafif pozitiftir. Daidzein ile tedavi edilen gruplarda SOD aktivite seviyesi artarken, MDA seviyeleri azaldı. Ayrıca I/R + DZ70 ve IR+DZ35 gruplarında I/R grubuna göre doza bağlı olarak kanama alanları ve inflamatuar hücre göçü azaldı.
Sonuç: Daidzein, over iskemi-reperfüzyon hasarının tedavisinde güçlü bir koruyucu role sahiptir ve terapötik bir ajan olarak kullanılabilir.

References

  • Aslan M, Erkanli Senturk G, Akkaya H, Sahin S and Yilmaz B. The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats. Taiwan J Obstet Gynecol. 2017;56:456-62.
  • Fazilet B, Süleyman G, Emine G, Mehtap P. Overview of ovarian torsion. Kocatepe Med J. 2016;17:30-35.
  • Srivastava G, Mehta JL. Currying the heart: curcumin and cardioprotection. J Cardiovasc Pharmacol Ther. 2009;14:22-27.
  • Chen M, Chen CD, Yang YS. Torsion of the previously normal uterine adnexa. Evaluation of the correlation between the pathological changes and the clinical characteristics. Acta Obstet Gynecol Scand. 2001;80:58-61.
  • Halici Z, Karaca M, Keles ON, Borekci B, Odabasoglu F, Suleyman H et al. Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation. Fertility and sterility. 2008;90:2408-15.
  • Geyikoglu F, Koc K, Erol HS, Colak S, Ayer H, Jama S et al. The propolis and boric acid can be highly suitable, alone/or as a combinatory approach on ovary ischemia-reperfusion injury. Arch Gynecol Obstet. 2019;300:1405-12.
  • Ersoz N, Guven A, Cayci T, Uysal B, Turk E, Oztas E et al. Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. Ren Fail. 2009;31:704-10.
  • Kesik V, Guven A, Vurucu S, Tunc T, Uysal B, Gundogdu G et al. Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion. J Surg Res. 2009;157:e97-e105.
  • Nayki UA, Nayki C, Cetin N, Cimen FK, Coban A, Mammadov R et al. Effect of Kineret(R) on ovarian ischemia reperfusion injury in a rat model. J Obstet Gynaecol Res. 2016;42:1525-33.
  • Oguzhan O, Huseyin E, Gokhan C, Zafer Y. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest. 2015;6:331-36.
  • Zhang F, Ru N, Shang ZH, Chen JF, Yan C, Li Y et al. Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits in Sprague-Dawley rats through PI3K/Akt signaling pathway. Exp Ther Med. 2017;14:4878-86.
  • Rufer CE, Kulling SE. Antioxidant activity of isoflavones and their major metabolites using different in vitro assays. J Agric Food Chem. 2006;54:2926-31.
  • L'Homme R, Brouwers E, Al-Maharik N, Lapcik O, Hampl R, Mikola H et al. Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensin. J Steroid Biochem Mol Biol. 2002;81:353-61.
  • Choi EJ and Kim GH. The antioxidant activity of daidzein metabolites, Odesmethylangolensin and equol, in HepG2 cells. Mol Med Rep. 2014;9:328-32.
  • Li HY, Pan L, Ke YS, Batnasan E, Jin XQ, Liu ZY et al. Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-alpha-stimulated murine lung epithelial cells via depressing PARP-1 activity. Acta Pharmacol Sin. 2014;35:496-503.
  • Tanaka K, Ohgo Y, Katayanagi Y, Yasui K, Hiramoto S, Ikemoto H et al. Anti-inflammatory effects of green soybean extract irradiated with visible light. Sci Rep. 2014;4:4732.
  • Sosic-Jurjevic B, Lutjohann D, Renko K, Filipovic B, Radulovic N, Ajdzanovic V et al. The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats. J Steroid Biochem Mol Biol. 2019;190:1-10.
  • Yayla M, Cetin D, Adali Y, Kilicle PA, Toktay E. Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats. Iran J Basic Med Sci. 2018;21:1262-8.
  • Cadirci E, Halici Z, Yayla M, Toktay E, Bayir Y, Karakus E et al. Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats. Peptides. 2016;82:35-43.
  • Klein M, Vignaud JM, Hennequin V, Toussaint B, Bresler L, Plenat F et al. Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma. J Clin Endocr Metab. 2001;86:656-58.
  • Cowled P, Fitridge R. Pathophysiology of reperfusion injury. In Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists (Eds R Fitridge, M Thompson): 331-50. Adelaide (AU), Barr Smith Press, 2011. .
  • Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 2012;298:229-317.
  • Zweier JL , Talukder MA. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res. 2006;70:181-90.
  • Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW et al. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem. 2018;46:1650-67.
  • Sahin L, Sarihan M, Parlakpinar H, Polat A, Vardi N. The effects of vinpocetine on the prevention and treatment of the ischemia/reperfusion injury: An experimental study. Acta Medica Mediterranea. 2017;33:857- 62.
  • Soares ROS, Losada DM, Jordani MC, Evora P, Castro ESO. Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies. Int J Mol Sci. 2019;20:5034.
  • Topcu A, Balik G, Atak M, Mercantepe T, Uydu HA, Tumkaya L. An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats. Eur J Pharmacol. 2019;865:172790.
  • Yurtcu E, Togrul C, Ozyer S, Uzunlar O, Karatas YH, Seckin KD et al. Dose dependent protective effects of vardenafil on ischemia-reperfusion injury with biochemical and histopathologic evaluation in rat ovary. J Pediatr Surg. 2015;50:1205-9.
  • Ergun Y, Koc A, Dolapcioglu K, Akaydin Y, Dogruer G, Kontas T et al. The protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovary. Eur J Obstet Gynecol Reprod Biol. 2010;152:186-90.
  • Ural DA, Aykan DA, Koçarslan S, Doğaner A. Effect of tadalafil treatment on ovarian ischemia injury in rats. Cukurova Medical Journal . 2021;46:55-62.
  • Aras AB, Guven M, Akman T, Ozkan A, Sen HM, Duz U et al. Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats. Neural Regen Res. 2015;10:146-52.
  • Ito F, Sono Y, Ito T. Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic inflammation. Antioxidants (Basel). 2019;8.
  • Sener G, Mustafa B. The protective effect of letrozole in a rat ovarianischemia-reperfusion injury model. Van Medical Journal. 2020;27:407-14.
  • Nuri Y, Gurkan Y, Alkim G, Yildirim A, Orkun İ, Ozgur Y et al. Octreotide protects ovary against ischemia–reperfusion injury in rats: Evaluation of histological and biochemical parameters. J Obstet Gynaecol Res. 2015;41:1591-97.
  • Patel RP, Boersma BJ, Crawford JH, Hogg N, Kirk M, Kalyanaraman B et al. Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. Free Radic Biol Med. 2001;31:1570-81.
  • Boersma BJ, Patel RP, Kirk M, Jackson PL, Muccio D, Darley-Usmar VM et al. Chlorination and nitration of soy isoflavones. Arch Biochem Biophys. 1999;368:265-75.
  • Lai HH, Yen GC. Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation. Biosci Biotechnol Biochem. 2002;66:22-8.
  • Behroozi-Lak T, Zarei L, Moloody-Tapeh M, Farhad N, Mohammadi R. Protective effects of intraperitoneal administration of nimodipine on ischemia-reperfusion injury in ovaries: Histological and biochemical assessments in a rat model. J Pediatr Surg. 2017;52:602-8.
  • Gedik E, Girgin S, Ozturk H, Obay BD, Ozturk H, Buyukbayram H. Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats. World J Gastroenterol. 2008;14:7101-6.
  • Somuncu S, Cakmak M, Dikmen G, Akman H, Kaya M. Ischemia-reperfusion injury of rabbit ovary and protective effect of trapidil: an experimental study. Pediatr Surg Int. 2008;24:315-8.
  • Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC. Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol. 1999;163:3963-8.
  • Bayir Y, Cadirci E, Polat B, Kilic Baygutalp N, Albayrak A, Karakus E et al. Aliskiren - a promising strategy for ovarian ischemia/reperfusion injury protection in rats via RAAS. Gynecol Endocrinol. 2016;32:675-83.
  • Yu J, Bi X, Yu B, Chen D. Isoflavones: anti-inflammatory benefit and possible caveats. Nutrients. 2016;8:361.
  • Choi EY, Jin JY, Lee JY, Choi JI, Choi IS, Kim SJ. Anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with Prevotella intermedia lipopolysaccharide. J Periodontal Res. 2012;47:204-11.
  • Marzocchella L, Fantini M, Benvenuto M, Masuelli L, Tresoldi I, Modesti A et al. Dietary flavonoids: molecular mechanisms of action as anti- inflammatory agents. Recent Pat Inflamm Allergy Drug Discov. 2011;5:200-20.
  • Paradkar PN, Blum PS, Berhow MA, Baumann H, Kuo SM. Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine. Cancer Lett. 2004;215:21-8.
  • Lesinski GB, Reville PK, Mace TA, Young GS, Ahn-Jarvis J, Thomas-Ahner J et al. Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced proinflammatory cytokines and immunosuppressive cells. Cancer Prev Res (Phila). 2015;8:1036-44.
  • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495-516.
  • Harrison DC, Davis RP, Bond BC, Campbell CA, James MF, Parsons AA et al. Caspase mRNA expression in a rat model of focal cerebral ischemia. Brain Res Mol Brain Res. 2001;89:133-46.
  • Cakir N, Gencer M, Karaca T, Hacivelioglu S, Uysal A, Korkmaz F et al. The effect of hesperetin on ischemia-reperfusion injury in rat ovary. Arch Gynecol Obstet. 2014;290:763-9.
  • Rivera P, Perez-Martin M, Pavon FJ, Serrano A, Crespillo A, Cifuentes M et al. Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus. PLoS One. 2013;8:e64750.
  • Aras AB, Guven M, Akman T, Ozkan A, Sen HM, Duz U et al. Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats. Neural Regen Res. 2015;10:146-52.
  • Liu R, Zhong X, Zeng J, Huang Z, Li X, Xiao H et al. 3'-Daidzein sulfonate sodium inhibits neuronal apoptosis induced by cerebral ischemia-reperfusion. Int J Mol Med. 2017;39:1021-8.

Protective effect of daidzein on ovarian ischemia‑reperfusion injury in rats

Year 2022, Volume: 47 Issue: 1, 102 - 110, 31.03.2022
https://doi.org/10.17826/cumj.993250

Abstract

Purpose: In this study, our aim was to investigate the potential effects of strong antioxidant daidzein (DZ) on ovarian ischemia and reperfusion injury.
Materials and Methods: A total of 42 female Sprague-Dawley rats were randomly divided into seven groups. For the experimental model, the clamps were removed after 3 hours of ischemia, and blood flow was provided again. Then, reperfusion process was terminated for 3 hours. Daidzein was orally administered to animals at doses of 35 and 70 mg/kg 30 minutes before ischemia (I) and ischemia and reperfusion (I/R) procedures.
Results: Severe immunoreactivity of the IL-1β, IL-6 and Caspase-3 were detected in I and I/R groups. Moderate immunoreactivity of IL-1β, IL-6 and Caspase-3 was detected in I+DZ35 and I/R+DZ35 groups, and slightly positivity was detected in I+DZ70 and I/R+DZ70 groups. The SOD activity level increased in the groups treated with Daidzein, while MDA levels decreased. In addition, hemorrhage areas and inflammatory cell migration decreased in I/R+DZ70 and I/R+DZ35 groups, when compared to I/R group in a dose dependent manner.
Conclusion: Daidzein has a strong protective role in the treatment of ovarian ischemia-reperfusion injury and can be used as a therapeutic agent.

References

  • Aslan M, Erkanli Senturk G, Akkaya H, Sahin S and Yilmaz B. The effect of oxytocin and Kisspeptin-10 in ovary and uterus of ischemia-reperfusion injured rats. Taiwan J Obstet Gynecol. 2017;56:456-62.
  • Fazilet B, Süleyman G, Emine G, Mehtap P. Overview of ovarian torsion. Kocatepe Med J. 2016;17:30-35.
  • Srivastava G, Mehta JL. Currying the heart: curcumin and cardioprotection. J Cardiovasc Pharmacol Ther. 2009;14:22-27.
  • Chen M, Chen CD, Yang YS. Torsion of the previously normal uterine adnexa. Evaluation of the correlation between the pathological changes and the clinical characteristics. Acta Obstet Gynecol Scand. 2001;80:58-61.
  • Halici Z, Karaca M, Keles ON, Borekci B, Odabasoglu F, Suleyman H et al. Protective effects of amlodipine on ischemia-reperfusion injury of rat ovary: biochemical and histopathologic evaluation. Fertility and sterility. 2008;90:2408-15.
  • Geyikoglu F, Koc K, Erol HS, Colak S, Ayer H, Jama S et al. The propolis and boric acid can be highly suitable, alone/or as a combinatory approach on ovary ischemia-reperfusion injury. Arch Gynecol Obstet. 2019;300:1405-12.
  • Ersoz N, Guven A, Cayci T, Uysal B, Turk E, Oztas E et al. Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS. Ren Fail. 2009;31:704-10.
  • Kesik V, Guven A, Vurucu S, Tunc T, Uysal B, Gundogdu G et al. Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion. J Surg Res. 2009;157:e97-e105.
  • Nayki UA, Nayki C, Cetin N, Cimen FK, Coban A, Mammadov R et al. Effect of Kineret(R) on ovarian ischemia reperfusion injury in a rat model. J Obstet Gynaecol Res. 2016;42:1525-33.
  • Oguzhan O, Huseyin E, Gokhan C, Zafer Y. Oxidative stress and its impacts on intracellular lipids, proteins and DNA. J Clin Exp Invest. 2015;6:331-36.
  • Zhang F, Ru N, Shang ZH, Chen JF, Yan C, Li Y et al. Daidzein ameliorates spinal cord ischemia/reperfusion injury-induced neurological function deficits in Sprague-Dawley rats through PI3K/Akt signaling pathway. Exp Ther Med. 2017;14:4878-86.
  • Rufer CE, Kulling SE. Antioxidant activity of isoflavones and their major metabolites using different in vitro assays. J Agric Food Chem. 2006;54:2926-31.
  • L'Homme R, Brouwers E, Al-Maharik N, Lapcik O, Hampl R, Mikola H et al. Time-resolved fluoroimmunoassay of plasma and urine O-desmethylangolensin. J Steroid Biochem Mol Biol. 2002;81:353-61.
  • Choi EJ and Kim GH. The antioxidant activity of daidzein metabolites, Odesmethylangolensin and equol, in HepG2 cells. Mol Med Rep. 2014;9:328-32.
  • Li HY, Pan L, Ke YS, Batnasan E, Jin XQ, Liu ZY et al. Daidzein suppresses pro-inflammatory chemokine Cxcl2 transcription in TNF-alpha-stimulated murine lung epithelial cells via depressing PARP-1 activity. Acta Pharmacol Sin. 2014;35:496-503.
  • Tanaka K, Ohgo Y, Katayanagi Y, Yasui K, Hiramoto S, Ikemoto H et al. Anti-inflammatory effects of green soybean extract irradiated with visible light. Sci Rep. 2014;4:4732.
  • Sosic-Jurjevic B, Lutjohann D, Renko K, Filipovic B, Radulovic N, Ajdzanovic V et al. The isoflavones genistein and daidzein increase hepatic concentration of thyroid hormones and affect cholesterol metabolism in middle-aged male rats. J Steroid Biochem Mol Biol. 2019;190:1-10.
  • Yayla M, Cetin D, Adali Y, Kilicle PA, Toktay E. Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats. Iran J Basic Med Sci. 2018;21:1262-8.
  • Cadirci E, Halici Z, Yayla M, Toktay E, Bayir Y, Karakus E et al. Blocking of urotensin receptors as new target for treatment of carrageenan induced inflammation in rats. Peptides. 2016;82:35-43.
  • Klein M, Vignaud JM, Hennequin V, Toussaint B, Bresler L, Plenat F et al. Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma. J Clin Endocr Metab. 2001;86:656-58.
  • Cowled P, Fitridge R. Pathophysiology of reperfusion injury. In Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists (Eds R Fitridge, M Thompson): 331-50. Adelaide (AU), Barr Smith Press, 2011. .
  • Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 2012;298:229-317.
  • Zweier JL , Talukder MA. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res. 2006;70:181-90.
  • Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW et al. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol Biochem. 2018;46:1650-67.
  • Sahin L, Sarihan M, Parlakpinar H, Polat A, Vardi N. The effects of vinpocetine on the prevention and treatment of the ischemia/reperfusion injury: An experimental study. Acta Medica Mediterranea. 2017;33:857- 62.
  • Soares ROS, Losada DM, Jordani MC, Evora P, Castro ESO. Ischemia/reperfusion injury revisited: an overview of the latest pharmacological strategies. Int J Mol Sci. 2019;20:5034.
  • Topcu A, Balik G, Atak M, Mercantepe T, Uydu HA, Tumkaya L. An investigation of the effects of metformin on ovarian ischemia-reperfusion injury in rats. Eur J Pharmacol. 2019;865:172790.
  • Yurtcu E, Togrul C, Ozyer S, Uzunlar O, Karatas YH, Seckin KD et al. Dose dependent protective effects of vardenafil on ischemia-reperfusion injury with biochemical and histopathologic evaluation in rat ovary. J Pediatr Surg. 2015;50:1205-9.
  • Ergun Y, Koc A, Dolapcioglu K, Akaydin Y, Dogruer G, Kontas T et al. The protective effect of erythropoietin and dimethylsulfoxide on ischemia-reperfusion injury in rat ovary. Eur J Obstet Gynecol Reprod Biol. 2010;152:186-90.
  • Ural DA, Aykan DA, Koçarslan S, Doğaner A. Effect of tadalafil treatment on ovarian ischemia injury in rats. Cukurova Medical Journal . 2021;46:55-62.
  • Aras AB, Guven M, Akman T, Ozkan A, Sen HM, Duz U et al. Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats. Neural Regen Res. 2015;10:146-52.
  • Ito F, Sono Y, Ito T. Measurement and clinical significance of lipid peroxidation as a biomarker of oxidative stress: oxidative stress in diabetes, atherosclerosis, and chronic inflammation. Antioxidants (Basel). 2019;8.
  • Sener G, Mustafa B. The protective effect of letrozole in a rat ovarianischemia-reperfusion injury model. Van Medical Journal. 2020;27:407-14.
  • Nuri Y, Gurkan Y, Alkim G, Yildirim A, Orkun İ, Ozgur Y et al. Octreotide protects ovary against ischemia–reperfusion injury in rats: Evaluation of histological and biochemical parameters. J Obstet Gynaecol Res. 2015;41:1591-97.
  • Patel RP, Boersma BJ, Crawford JH, Hogg N, Kirk M, Kalyanaraman B et al. Antioxidant mechanisms of isoflavones in lipid systems: paradoxical effects of peroxyl radical scavenging. Free Radic Biol Med. 2001;31:1570-81.
  • Boersma BJ, Patel RP, Kirk M, Jackson PL, Muccio D, Darley-Usmar VM et al. Chlorination and nitration of soy isoflavones. Arch Biochem Biophys. 1999;368:265-75.
  • Lai HH, Yen GC. Inhibitory effect of isoflavones on peroxynitrite-mediated low-density lipoprotein oxidation. Biosci Biotechnol Biochem. 2002;66:22-8.
  • Behroozi-Lak T, Zarei L, Moloody-Tapeh M, Farhad N, Mohammadi R. Protective effects of intraperitoneal administration of nimodipine on ischemia-reperfusion injury in ovaries: Histological and biochemical assessments in a rat model. J Pediatr Surg. 2017;52:602-8.
  • Gedik E, Girgin S, Ozturk H, Obay BD, Ozturk H, Buyukbayram H. Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats. World J Gastroenterol. 2008;14:7101-6.
  • Somuncu S, Cakmak M, Dikmen G, Akman H, Kaya M. Ischemia-reperfusion injury of rabbit ovary and protective effect of trapidil: an experimental study. Pediatr Surg Int. 2008;24:315-8.
  • Carlson NG, Wieggel WA, Chen J, Bacchi A, Rogers SW, Gahring LC. Inflammatory cytokines IL-1 alpha, IL-1 beta, IL-6, and TNF-alpha impart neuroprotection to an excitotoxin through distinct pathways. J Immunol. 1999;163:3963-8.
  • Bayir Y, Cadirci E, Polat B, Kilic Baygutalp N, Albayrak A, Karakus E et al. Aliskiren - a promising strategy for ovarian ischemia/reperfusion injury protection in rats via RAAS. Gynecol Endocrinol. 2016;32:675-83.
  • Yu J, Bi X, Yu B, Chen D. Isoflavones: anti-inflammatory benefit and possible caveats. Nutrients. 2016;8:361.
  • Choi EY, Jin JY, Lee JY, Choi JI, Choi IS, Kim SJ. Anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with Prevotella intermedia lipopolysaccharide. J Periodontal Res. 2012;47:204-11.
  • Marzocchella L, Fantini M, Benvenuto M, Masuelli L, Tresoldi I, Modesti A et al. Dietary flavonoids: molecular mechanisms of action as anti- inflammatory agents. Recent Pat Inflamm Allergy Drug Discov. 2011;5:200-20.
  • Paradkar PN, Blum PS, Berhow MA, Baumann H, Kuo SM. Dietary isoflavones suppress endotoxin-induced inflammatory reaction in liver and intestine. Cancer Lett. 2004;215:21-8.
  • Lesinski GB, Reville PK, Mace TA, Young GS, Ahn-Jarvis J, Thomas-Ahner J et al. Consumption of soy isoflavone enriched bread in men with prostate cancer is associated with reduced proinflammatory cytokines and immunosuppressive cells. Cancer Prev Res (Phila). 2015;8:1036-44.
  • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495-516.
  • Harrison DC, Davis RP, Bond BC, Campbell CA, James MF, Parsons AA et al. Caspase mRNA expression in a rat model of focal cerebral ischemia. Brain Res Mol Brain Res. 2001;89:133-46.
  • Cakir N, Gencer M, Karaca T, Hacivelioglu S, Uysal A, Korkmaz F et al. The effect of hesperetin on ischemia-reperfusion injury in rat ovary. Arch Gynecol Obstet. 2014;290:763-9.
  • Rivera P, Perez-Martin M, Pavon FJ, Serrano A, Crespillo A, Cifuentes M et al. Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus. PLoS One. 2013;8:e64750.
  • Aras AB, Guven M, Akman T, Ozkan A, Sen HM, Duz U et al. Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats. Neural Regen Res. 2015;10:146-52.
  • Liu R, Zhong X, Zeng J, Huang Z, Li X, Xiao H et al. 3'-Daidzein sulfonate sodium inhibits neuronal apoptosis induced by cerebral ischemia-reperfusion. Int J Mol Med. 2017;39:1021-8.
There are 53 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research
Authors

Erdem Toktay 0000-0002-7447-6023

Muhammet Ali Gürbüz 0000-0001-6628-3363

Tuğba Bal 0000-0001-8257-8639

Özlem Özgül 0000-0001-9852-8839

Elif Erbaş 0000-0003-1750-3889

Rüstem Anıl Ugan 0000-0002-4837-2343

Jale Selli 0000-0002-1750-1130

Publication Date March 31, 2022
Acceptance Date January 4, 2022
Published in Issue Year 2022 Volume: 47 Issue: 1

Cite

MLA Toktay, Erdem et al. “Protective Effect of Daidzein on Ovarian ischemia‑reperfusion Injury in Rats”. Cukurova Medical Journal, vol. 47, no. 1, 2022, pp. 102-10, doi:10.17826/cumj.993250.