@article{article_283870, title={The outbreak of Acinetobacter baumannii producing OXA-23 and OXA-51 type carbapenemases in a state hospital}, journal={Journal of Experimental and Clinical Medicine}, volume={33}, pages={157–161}, year={2017}, author={Guven Gokmen, Tulin and Akcimen, Beril and Kayar, Begum and Marzi, Mahdi and Koksal, Fatih}, keywords={A. baumannii,Outbreak,OXA-23,OXA-51}, abstract={<p class="p1"> <br> </p> <p> </p> <table cellspacing="0" cellpadding="0" class="t1"> <tbody> <tr> <td valign="top" class="td1"> <p class="p2"> <span class="s1">  </span> <i>Acinetobacter baumannii </i>is non-fermentative gram-negative bacilli which plays an important pathogen especially in intensive care units causing infections and epidemics. Carbapenem resistance often is consisted of OXA-type carbapenemase. In this study, we aimed to determine carbapenem resistance and clonal relationships of <i>A. baumannii </i>isolated from patient and enviromental samples by phenotypic and genotypic methods in 10-bed intensive care unit. Multiplex-PCR method was used to determine the genes of OXA type beta-lactamases (blaOXA) and clonal relations between strains were investigated by pulsed-field gel electrophoresis (PFGE) method. All of the isolates were found to be carbapenem resistant and had the blaOXA-51-like and blaOXA-23-like gene. Also, all of isolates were seen to be 100 % related by PFGE method. As a result, isolates of patients with ventilator-associated pneumonia and isolates survived on ventilator of Intensive Care Unit were found to be 100% clonal associated with PFGE and had same MIC values for imipenem and meropenem. blaOXA-23 and blaOXA-51 genes has been determined all of the isolates. It can be accepted a short-term and small outbreak.  </p> </td> </tr> </tbody> </table>}, number={3}, publisher={Ondokuz Mayıs University} }